Hugo Lloris is likewise sidelined so Fraser Forster will continue in between the sticks however Cristian Romero is available once again after serving a one-match domestic restriction for the 4-1 defeat to Leicester on Saturday.
Ryan Sessegnon is Spurs’ other hurt gamer after getting a hamstring injury in training.
Clement Lenglet might be chosen to Ben Davies in the back 3 while Emerson Royal is anticipated to return at best wing-back in location of Pedro Porro, who sustained a hard launching versus the Foxes.
Dejan Kulsevski, who signed up with Antonio Conte at his pre-match interview, and Heung-minutes Son are anticipated to continue in the 3 front with Harry Kane, leaving Richarlison and Arnaut Danjuma in reserve.
Predicted Tottenham XI (3-4-3): Forster; Romero, Dier, Lenglet; Emerson, Skipp, Sarr, Perisic; Kulusevski, Son, Kane.