How 3D printers might help enhance access to eye care

Unlike a basic printer that prints words and images onto a flat sheet of paper, 3D printing produces a real three-dimensional product.

The 3D printer does this by utilizing “printing” layers of product. These layers continue to build and shape into the item it is printing. Because of this, 3D printing is thought about an additive innovation.

A range of products consisting of plastics, metals, composites, and ceramics can be utilized to 3D print items.

For 3D printing medical gadgets, the Food & Drug Administration (FDA) presently controls these products through its Center for Devices and Radiological Health (CDRH).

According to Dr. Alex Hui, the head of biosciences at the Centre for Ocular Research & Education (CORE) at the University of Waterloo, the essential advantage of 3D printing is versatility.

“3D printing opens new avenues for rapid, on-demand, and custom manufacturing of ocular devices, ranging from glasses, contact lenses, or drug-delivering ocular inserts,” he informed Medical News Today. “We can also leverage this technology to make better in vitro eye models to screen drugs or test new ocular products.”

“While the potential of 3D printing in eye care is quite promising, we are still quite far away from this reality,” Hui included. “That is precisely why we have decided to pursue this research, helping bridge the gap between 3D printing and ophthalmic applications.”

This is not the very first time researchers have actually taken a look at 3D printing in eye health. A research study in December 2022 revealed how 3D bioprinting might be utilized to produce eye tissue. Other research study has actually taken a look at 3D printing for contact lenses and intraocular lenses.

“From a consumer perspective, 3D printing allows for medical devices to potentially be produced at the point of care — e.g., in the office or home,” Hui said. “The most useful application will be for situations needing a customized, one-off, or specialty design for a unique patient. We envision this technology could be impactful in scleral lenses, orthokeratology, and drug delivery where custom and personalized products are highly desirable. Products that have a short shelf life or products that take weeks or months to produce may also benefit from this technology.”

Three of the 3D printing developments focused on the making and usage of 3D-printed polydimethyl siloxane (PDMS) microfluidic chips.

Researchers took a look at utilizing this chip to test eye cell reactions to particular conditions, in addition to utilizing the chip to make a contact lens that can test medications administered through the eyes.

Additionally, researchers had the ability to include human corneal epithelial cells (HCECs) into the PDMS chip for usage in cell biological research studies.

“Microfluidic devices are a common tool used in research and diagnostics,” Hui explained. “For example, consider COVID test strips that use similar principles, where only a small amount of fluid is leveraged for information. Those made from PDMS are primarily used for research containing cells, but the traditional process to make PDMS microfluidic devices is quite lengthy and expensive.”

“CORE leveraged 3D printing as a way to help facilitate this process, enabling us to create design elements that would normally not be possible using traditional approaches,” he continued. “We utilize these PDMS chips to help test and screen new drugs and products on cells in terms of safety and efficacy. We can also design these chips in the future as a diagnostic tool, such as detecting tear film biomarkers for specific eye diseases, in a relatively rapid fashion from design to the first prototypes.”

Another research study concentrated on the advancement of a naturally degradable bioink for 3D printing ophthalmic gadgets.

In this research study, scientists utilized the bioink to 3D print products that can be utilized to make eco-friendly contact lenses.

“Bioinks are materials that have a compatible biological profile that can also be printed using a 3D printer,” Hui said. “We want to utilize this technology to print biodegradable ocular inserts for drug delivery, and their geometrical designs are quite simple, making this straightforward.”

“As a learning exercise, we also wanted to see if we could print a soft contact lens, which (is) very thin and soft, and for which there are numerous challenges to have it print properly,” he included. “We will use the lessons learned and apply them for 3D printing hard lenses — i.e., scleral lenses and ortho-K lenses.”

CORE scientists likewise established a soft hydrogel eye design with surface areas simulating the natural surface areas of the cornea and sclera. The design likewise has an internal chamber to simulate the natural interior of the eye.

Researchers think this kind of eye design might be utilized for evaluating the administration of eye medications and how they are soaked up through the cornea.

“There are a lot of studies that require us to understand how drugs diffuse and penetrate to the back of the eye, and there has been no way to simulate that,” Hui explained. “By experimenting with different bioink formulations, we can now 3D print a hydrogel eyeball with hollow structures that simulate the anterior and posterior chambers. Further advances will help us study various drug delivery methods to the back of the eye. As our work develops, we hope to produce models for not only research but also educational purposes, allowing clinicians to learn and practice techniques on them prior to patient interactions.”

Medical News Today likewise talked to Dr. Benjamin Bert, an eye doctor at MemorialCare Orange Coast Medical Center in California, about this research study.

“Any application of new technologies that we’re able to use to try to improve the care that we provide and brings things into the future is always beneficial and always very exciting,” said Bert, who was not associated with this specific research study.

When speaking of the advantages 3D printing might use eye care specialists in the future, Bert said it will open ease of access.

“So you can have a technology that is developed in one part of the world, and then by being able to print it with just having access to a 3D printer, that means you can bring it into even very remote parts and still have access to this highly advanced technology,” he said.

“I think it is a very interesting technology,” Bert included. “It has a lot of future applications. And this was kind of the first step in introducing some of the things where it may be able to be utilized. I think we’ll be hearing a lot more about it as time passes and as the research continues to progress.”